LOZART
Losartan Potassium Tablets USP
Losartan is a selective, competitive angiotensin-II receptor type 1 (AT-1 type) antagonist, which reduces the end organ responses to angiotensin-II, which binds to the AT-1 receptor found in many tissues (eg. vascular smooth muscle, adrenal gland, kidneys and the heart) and stimulates several biological actions, including vasoconstriction and the release of aldosterone that ultimately contributes to hypertension.
- Tablet 25mg
- Tablet 50mg
- Share on
Hypertension including;
· Left ventricular hypertrophy
· Diabetic nephropathy in type 2 diabetes mellitus,
Hypertension (including reduction of stroke risk in hypertension with left ventricular hypertrophy)
Adult: 18-75 years: Initially 50 mg once daily for several weeks, then increased, if necessary, to l00 mg once daily or as directed by the physcian.
Adult: 76 years and over: Initially 25 mg once for several weeks, then increased, if necessary, to l00 mg once dailyor as directed by the physcian.
Hypertension with intravascular volume depletion
Adult: 18-75 years: Initially 25 mg once daily for several weeks, then increased if necessary, up to l00 mg once dailyor as directed by the physcian.
Diabetic nephropathy in type 2 diabetes mellitus
Adult: 18-75 years: Initially 50 mg once daily for several weeks, then increased if necessary to l00 mg once daily or as directed by the physcian.
Adult: 76 years and over: Initially 25 mg once daily for several weeks, then increased if necessary to l00 mg once dailyor as directed by the physcian.
Chronic heart failure when ACE inhibitors are unsuitable or contra-indicated
Adult: Initially 12.5 mg once daily, increased if tolerated to up to l50 mg once daily, doses to be increased at weekly intervals.
